4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-
ARRY-380
CAS: 937263-43-9
Molecular Formula: C26H24N8O2
4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- - Names and Identifiers
4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- - Physico-chemical Properties
| Molecular Formula | C26H24N8O2 |
| Molar Mass | 480.52 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| pKa | 6.61±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | ARRY-380 is a reversible, ATP-competitive inhibitor with a nanomolar inhibitory effect on ErbB2 in vitro and in cell assays. In cell experiments, ARRY-380 was 500-fold more selective for HER2 than for EGFR, and was as potent for truncated p95-HER2 as for HER2. |
| In vivo study | ARRY-380 was able to inhibit tumor growth in a variety of her2-dependent tumor xenograft models. In many mouse tumor models, such as breast tumor (BT-474, MDA-MB-453), ovarian tumor (SKOV-3), gastric cancer (N87) model, have higher activity. In BT-474 models, ARRY-380 significantly inhibited tumor growth in a dose-dependent manner and mostly regressed. |
4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.081 ml | 10.405 ml | 20.811 ml |
| 5 mM | 0.416 ml | 2.081 ml | 4.162 ml |
| 10 mM | 0.208 ml | 1.041 ml | 2.081 ml |
| 5 mM | 0.042 ml | 0.208 ml | 0.416 ml |
Last Update：2024-01-02 23:10:35
![4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-](http://res.chembk.com/assets/str/2d/9/93/937263-43-9.png)
Supplier List
Spot supply
Product Name: ARRY-380 Visit Supplier Webpage Request for quotationCAS: 937263-43-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: ARRY-380 Visit Supplier Webpage Request for quotationCAS: 937263-43-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History